Is There a Relation Between Family History of Different Types of Cancers with the Development of Endometrial Cancer and Menopausal State?

Section: Research Paper
Issue
Vol. 47 No. 2 (2025): Volume 47 Issue 2
Published
Dec 29, 2025
Pages
194-199

Abstract

Objectives: To determine whether the family's history of colonic, uterine, breast, or other malignancies raises the risk of developing cancer of the endometrium in women in Nineveh Province, northern Iraq.


Subjects and Methods: A case-control study included 300 female participants: 100 with endometrial cancer and 200 age-matched controls. The researcher identified and selected cases from the medical records of the Oncology and Nuclear Medicine Hospital and its departments, then contacted them directly via phone. For the controls, the data were obtained during direct interviews with participants who were attending the local hospitals in Nineveh Province for non-neoplastic and non-gynecological conditions.


Results: The associations between familial history of colonic, uterine, or breast cancer in the first degree and the occurrence of cancer of the endometrium in the study sample groups revealed a risky association with a statistically significant difference (OR = 29.74, 95% CI = 3.83; 230.87, P > 0.001); (OR = 6.38, 95% CI = 2.71; 15.01, P > 0.001); (OR = 3.92, 95% CI = 1.83; 8.39, P = 0.002), respectively. However, no statistically significant difference exists between the occurrence of endometrial cancer and other forms of cancer. Furthermore, there is no statistically significant association between the family's history of cancer and menopausal status.


Conclusion: According to the study, a first-degree relative's family history of colonic, uterine, or breast cancer is significantly associated with an elevated risk of endometrial cancer. However, other malignancies and menopausal status have non-significant associations.

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Authors

Zahraa Dheyauldin Abdulwahhab

Nineveh Health Directorate, Ministry of Health

Humam Ghanim Ibrahim Zubeer

Department of Family and Community Medicine, College of Medicine, University of Mosul, Mosul, Iraq

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1.
Abdulwahhab ZD, Zubeer HGI. Is There a Relation Between Family History of Different Types of Cancers with the Development of Endometrial Cancer and Menopausal State?. Ann. coll. Med. Mosul [Internet]. 2025 Dec. 29 [cited 2026 Jan. 2];47(2):194-9. Available from: https://mmed.uomosul.edu.iq/index.php/mmed/article/view/60195