The Impact Of Obesity On Pulmonary Function

Section: Research Paper
Issue
Vol. 47 No. 2 (2025): Volume 47 Issue 2
Published
Dec 29, 2025
Pages
267-273

Abstract

Background: obesity generates a substantial worldwide health threat as it is being widely prevalent across the globe, including in Iraq, with notably among Baghdadi women. This rising prevalence of obesity has been associated with an increased incidence of various respiratory conditions.


Aim: This review highlights the special effect of obesity on respiratory parameters in healthy lung individuals and in individual with common pulmonary disease.


Method: This review was conducted through a comprehensive search of many literatures using electronic database.


Result: Literatures were selected based on effect of obesity on respiratory function in normal and respiratory diseased subjects.


Conclusion: Obesity primarily causes restrictive lung problems, but it can give rise to a slight obstructive difficulty, as exacerbation preexistent asthma. Pulmonary function is probably more directly impacted by central obesity. Forced vital capacity improves more in males than females after decreasing weight.


 

References

  1. Shafiee A, Nakhaee Z, Bahri RA, Amini MJ, Salehi A, Jafarabady K, Seighali N, Rashidian P, Fathi H, Esmaeilpur Abianeh F, Omran SP. Global prevalence of obesity and overweight among medical students: A systematic review and meta-analysis. BMC Public Health. 2024 Jun 24; 24(1):1673. doi: 10.1186/s12889-024-19184-4.
  2. Obesity and overweight. World Health Organization. Published June 9, 2021. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
  3. Jasim HM, Abdul Hussein HM, Al-Kaseer EA. Obesity among females in Al-Sader city Baghdad, Iraq, 2017. J Fac Med Baghdad [Internet]. 2018 Sep. 2 [cited 2024 Dec. 30]; 60(2):105-7.Available from: https://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/15
  4. Pengpid S, Peltzer K. Overweight and obesity among adults in Iraq: prevalence and correlates from a National Survey in 2015. International journal of environmental research and public health. 2021 Apr 15; 18(8):4198. doi: 10.3390/ijerph18084198
  5. Jastreboff AM, Kotz CM, Kahan S, Kelly AS, Heymsfield SB. Obesity as a disease: the obesity society 2018 position statement. Obesity. 2019 Jan; 27(1):7-9. doi: 10.1002/oby.22378.
  6. Kivimäki M, Strandberg T, Pentti J, Nyberg ST, Frank P, Jokela M, et al. Body mass index and risk of obesity related complex multimorbidity: An observational multicohort study. Lancet Diabetes Endocrinol.2022; 10:253 63. doi: 10.1016/S2213-8587(22)00033-X.
  7. Lam BC, Lim AY, Chan SL, Yum MP, Koh NS, Finkelstein EA. The impact of obesity: a narrative review. Singapore medical journal. 2023 Mar 1; 64(3):163-71. doi: 10.11622/smedj.2023036.
  8. Dixon AE, Bhatawadekar SA. Obesity, Lung Function, and Lung Disease. In Handbook of Obesity-Volume 1 2024 (pp. 548-555). CRC Press. doi: 10.1201/9781003437673-63.
  9. Dixon AE, Peters U. The effect of obesity on lung function. Expert Review of Respiratory Medicine. 2018 Sep; 12(9):755-767.doi: 10.1080/17476348.2018.1506331.
  10. Salome CM, King GG, Berend N. Physiology of obesity and effects on lung function. Journal of applied physiology. 2010 Jan; 108(1): 206-11. doi: 10.1152/japplphysiol.00918.2009.
  11. Mafort TT, Rufino R, Costa CH, Lopes AJ. Obesity: systemic and pulmonary complications, biochemical abnormalities, and impairment of lung function. Multidisciplinary respiratory medicine. 2016 Dec; 11:1-1. doi: 10.1186/s40248-016-0078-7.
  12. Rezoagli E, Bastia L. Obesity Enhances the Gravity Effect on the Respiratory System: The Importance of Monitoring Lung Mechanics. Chest. 2024 Mar 1; 165(3):475-7. doi: 10.1016/j.chest.2023.09.022.
  13. Rezoagli E, Bastia L, Brochard L, Bellani G. Physical manoeuvres in patients with ARDS and low compliance: bedside approaches to detect lung hyperinflation and optimise mechanical ventilation. European Respiratory Journal. 2023 May 1; 61(5). doi: 10.1183/13993003.00319-2023
  14. Rezoagli E, Bastia L, Grassi A, Chieregato A, Langer T, Grasselli G, et al. Paradoxical effect of chest wall compression on respiratory system compliance: a multicenter case series of patients with ARDS, with multimodal assessment. Chest. 2021 Oct 1; 160(4):1335-9. doi: 10.1016/j.chest.2021.05.578.
  15. Bastia L, Rezoagli E, Guarnieri M, Engelberts D, Forlini C, Marrazzo F, et al. External chest-wall compression in prolonged COVID-19 ARDS with low-compliance: a physiological study. Ann Intensive Care. 2022 Apr 12; 12(1):35. doi: 10.1186/s13613-022-01008-6. PMID: 35412161; PMCID: PMC9003155.
  16. Berra L, Grassi LG. Obesity and Mechanical Ventilation. InObesity and Lung Disease: A Guide to Pathophysiology, Evaluation, and Management 2024 May 28 (pp. 365-385). Cham: Springer International Publishing. doi: 10.1007/978-3-030-83692-1_16.
  17. Littleton SW. Impact of obesity on respiratory function. Respirology. 2012 Jan; 17(1):43-9. doi: 10.1111/j.1440-1843.2011.02014.x.
  18. Expert WH. Committee on Physical Status. The use and interpretation of anthropometry. Report of WHO expert committee. Geneva: WHO. 1995;854: 1-452. Available from: https://www.who.int/publications/i/item/9241208546.
  19. Brock JM, Billeter A, Müller-Stich BP, Herth F. Obesity and the Lung: What We Know Today. Respiration. 2020; 99(10):856-866. doi: 10.1159/000509735.
  20. Young R, Benjamin A. The assessment and management of obstructive sleep apnoea–hypopnoea syndrome and obesity hypoventilation syndrome in obesity. Clinical Medicine.2023Jul1; 23(4):372-9. doi: 10.7861/clinmed.2023-0152.
  21. Park Y, Kim J, Kim YS, Leem AY, Jo J, Chung K,et al. Longitudinal association between adiposity changes and lung function deterioration. Respiratory research. 2023 Feb 7; 24(1):44. https://doi.org/10.1186/s12931-023-02322-8.
  22. Hsu YE, Chen SC, Geng JH, Wu DW, Wu PY, Huang JC. Obesity-related indices are associated with longitudinal changes in lung function: a large Taiwanese population follow-up study. Nutrients. 2021 Nov 12;13(11):4055. doi: 10.3390/NU13114055.
  23. Svartengren M, Cai GH, Malinovschi A, Theorell-Haglöw J, Janson C, Elmståhl S, et al. The impact of body mass index, central obesity and physical activity on lung function: results of the EpiHealth study. ERJ Open Research. 2020 Oct 1; 6(4). doi: 10.1183/23120541.00380-2020.
  24. Peralta GP, Marcon A, Carsin AE, Abramson MJ, Accordini S, Amaral AF, et al. Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study. Thorax. 2020 Apr 1; 75(4):313-20. doi: 10.1136/thoraxjnl-2019-214460.
  25. Liu J, Xu H, Cupples LA, O' Connor GT, Liu CT. The impact of obesity on lung function measurements and respiratory disease: A Mendelian randomization study. Ann Hum Genet. 2023 Jul;87(4):174-183. doi: 10.1111/ahg.12506.
  26. Bermúdez Barón N, Kankaanranta H, Hedman L, Andersson M, Stridsman C, Lindberg A, et al. Body mass index increase: a risk factor for forced expiratory volume in 1 s decline for overweight and obese adults with asthma. ERJ Open Res. 2022 Oct 24;8(4):00110-2022. doi: 10.1183/23120541.00110-2022.
  27. Scott HA, Ng SH, McLoughlin RF, Valkenborghs SR, Nair P, Brown AC, et al. Effect of obesity on airway and systemic inflammation in adults with asthma: a systematic review and meta-analysis. Thorax. 2023 Oct; 78(10):957-965. doi: 10.1136/thorax-2022-219268.
  28. Alqarni AA, Aldhahir AM, Siraj RA, Alqahtani JS, Alshehri HH, Alshamrani AM, et al. Prevalence of Overweight and Obesity and Their Impact on Spirometry Parameters in Patients with Asthma: A Multicentre, Retrospective Study. J Clin Med. 2023 Feb 25; 12(5):1843. doi: 10.3390/jcm12051843.
  29. Tashiro H, Kurihara Y, Kuwahara Y, Takahashi K. Impact of obesity in asthma: Possible future therapies. Allergol Int. 2024 Jan; 73(1):48-57. doi: 10.1016/j.alit.2023.08.007.
  30. De Soomer K, Vaerenberg H, Weyler J, Pauwels E, Cuypers H, Verbraecken J, et al. Effects of Weight Change and Weight Cycling on Lung Function in Overweight and Obese Adults. Ann Am Thorac Soc. 2024 Jan; 21(1):47-55. doi: 10.1513/AnnalsATS.202212-1026OC.

Authors

Janan Abdalrazzak Alrefaee

Department of Medical Physiology, College of Medicine, University of Mosul, Mosul, Iraq Correspondence: [email protected]

Afraa Al Ameen

Department of Medical Physiology, College of Medicine, University of Mosul, Mosul, Iraq Correspondence: [email protected]

Identifiers

https://doi.org/10.33899/acmm.v47i2.60233
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1.
Alrefaee JA, Al Ameen A. The Impact Of Obesity On Pulmonary Function. Ann. coll. Med. Mosul [Internet]. 2025 Dec. 29 [cited 2026 Jan. 2];47(2):267-73. Available from: https://mmed.uomosul.edu.iq/index.php/mmed/article/view/60233