Influence of Age and Body Mass Index on Spirometry Parameters in Women with Hypothyroidism

Background: Thyroid hormones are essential for the function of the respiratory system. Hypothyroidism affects respiration by a decrease in lung compliance, muscle weakness, and a reduction in ventilatory drive. Lung function is influenced by age and body mass index, but the correlation of spirometry with BMI and age in hypothyroid women remains poorly understood.Aims: To investigate the effect of age and BMI on spirometry parameters in hypothyroid women in Nineveh Governorate.Materials and Methods: A case-control study of 50 newly diagnosed hypothyroidism and 50 euthyroid individuals. Measurement of spirometry parameters such as FVC, FEV1, and FEV1/FVC with a spirometer. Weight and height were measured to calculate BMI.Results: A significant negative correlation between age and FVC% was predicted in the hypothyroid group (r = -0.364, p = 0.009). Nevertheless, FEV1/FVC exhibited a significant negative correlation with BMI in the hypothyroid group (r = -0.296, p = 0.037).Conclusion: Lung function declines with age in women with hypothyroidism, especially FVC% predicted. BMI appears to increase the airflow limitation as pronounced by a decrease in FEV1/FVC in hypothyroid women.