Status of Vitamin D in Individuals with Type 2 Diabetes Mellitus

Section: Research Paper
Issue
Vol. 47 No. 2 (2025): Volume 47 Issue 2
Published
Dec 29, 2025
Pages
200-207

Abstract

Background: Recently, there has been an increasing interest towards the metabolic and clinical effects of vitamin D deficiency. Vitamin D has been suggested to impact glucose homeostasis and, thus, metabolic syndrome and type 2 diabetes mellitus (T2DM) seem to be linked to vitamin D deficiency.


Aim: To study serum “25-hydroxy vitamin D” levels in a group of T2DM patients and to investigate its possible influence on the degree of glycemic control and lipid metabolism.


Methods: This is a case- control study which enrolled 65 known cases of T2DM and 65 non- diabetic subjects. Blood levels of vitamin D, glycosylated hemoglobin (HbA1c), fasting serum lipids and plasma glucose (FPG) were measured. The impact of vitamin D levels on the extent of glycemic control and serum lipids was investigated.


Results: The mean serum level of vitamin D was significantly lower among T2DM patients compared to controls (p<0.0001). Vitamin D was significantly and inversely correlated with HbA1c and FPG values in diabetic patients (r= -0.54 and -0.578 respectively, p<0.0001). In addition, vitamin D showed negative correlations with serum triglycerides, total cholesterol, VLDL- cholesterol and low density lipoprotein cholesterol (LDL- c), but significant positive correlation with high density lipoprotein cholesterol (HDL- c).


Conclusions: Patients with T2DM frequently have vitamin D deficiency. Vitamin D insufficiency may be linked to poor glycemic control and dyslipidemia in T2DM patients. Vitamin D therapy may, thus, improve glycemic control in type 2 diabetes mellitus and ameliorate metabolic derangements.

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Authors

Sura Khairialdeen Mohialdeen

Department of Biochemistry, College of Medicine, University of Mosul

Saba Khairy Saleh

Department of Biochemistry, College of Medicine, University of Mosul

Amjad Hazim Al-Naemi

Department of Biochemistry, College of Medicine, University of Mosul

Ban Ali Hussein

Ibn-Sina Teaching Hospital, Nineveh Health Directorate , Mosul-iraq

Identifiers

https://doi.org/10.33899/acmm.v47i2.60196
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How to Cite

1.
Mohialdeen SK, Saleh SK, Al-Naemi AH, Hussein BA. Status of Vitamin D in Individuals with Type 2 Diabetes Mellitus. Ann. coll. Med. Mosul [Internet]. 2025 Dec. 29 [cited 2026 Jan. 2];47(2):200-7. Available from: https://mmed.uomosul.edu.iq/index.php/mmed/article/view/60196